Marathi Poem "Me AND My LOVE"
मी तिच्यात नव्हतो पण ती माझ्यात होती
मी तिच्यात नव्हतो पण ती माझ्यात होती
तीची नव्हती कधी पण माझी साथ होती
मी आजवर कदीलांच्या उजेडात जगलो
ती चमकणा-या ता-यांच्या प्रकाशात होती
तीचा प्रवास होता मोठ्या महामार्गावरचा
माझी ती बिचारी लहान पायवाट होती
तिच्या स्वप्नांना दोरखडं जखडलेले नेहमी
माझी कधीही सुटणारी निसरति गाठ होती
तीच सुखांशी नेहमी अजोड नातं गुफ़लेल
माझ्या वाट्याला दुःखंच भरमसाठ होती.
नेहमी साखर झोपेची तिची पहाट रोजची
मी डोळे मिटले नाही माझी सदा पहाट होती.
तिच्या ओठी नेहमी हसु उमलायच सुखाच
माझ्या डोळ्यानां नेहमी आसवांची साथ होती
तिने कधी हात जोडले नाहीत कशासाठी देवापुढे
तीच्यासाठी देवळात नेहमी माझीच वरात होती
आज म्हणतेय मी चुकली पण काय फ़ायदा
खरच फ़ार उशीरा तीची ही साद होती.
मी स्मशांन वाटेवर असताना तिला कळाल
आज म्हणे ती दिवसभर देवळात होती
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Thursday, March 25, 2010
Wednesday, March 24, 2010
Marathi Inspirative Poem जे घडेल ते सहन करायचे असतं
Writer say's,
What may happen? Live life with world.
life is like that.
when ever life is start but some where we have to stop.
we have to do something for some one.
जे घडेल ते सहन करायचे असतं, बदलत्या जगाबरोबर बदलायचं असतं
आयुष्य असचं जगायचं असतं
कुठून सुरु झालं हे माहीत नसलं तरी, कुठतरी थांबायचं असतं,
आयुष्य असचं जगायचं असतं
कुणासाठी काहीतरी निस्वार्थपणे करायचं असतं, स्वत च्या सुखापेक्षा इतरांना सुखवायचे असतं
आयुष्य असचं जगायचं असतं
दु ख आणि अश्रुंना मनात कोडुन ठेवायचं असतं, हसता नाही आलं तरी हसवायचं असतं,
आयुष्य असचं जगायचं असतं
पंखामध्ये बळ आल्यावर घरटं सोडायचं असतं, आकाशात झेपावुनही धरतीला विसरायचं नसतं,
आयुष्य असचं जगायचं असतं
मरणानं समोर येउन जीव जरी मागितला तरी मागुन मागुन काय मागितलसं असचं म्हणायचं असतं,
आयुष्य असचं जगायचं असतं
इच्छा असो वा नसो जन्मभर वाकायचं असतं, पणं जग सोडताना मात्र समाधानानं जायचं असतं,
आयुष्य असचं जगायचं असतं
आयुष्य असचं जगायचं असतं............
Life is like that??????????
What may happen? Live life with world.
life is like that.
when ever life is start but some where we have to stop.
we have to do something for some one.
जे घडेल ते सहन करायचे असतं, बदलत्या जगाबरोबर बदलायचं असतं
आयुष्य असचं जगायचं असतं
कुठून सुरु झालं हे माहीत नसलं तरी, कुठतरी थांबायचं असतं,
आयुष्य असचं जगायचं असतं
कुणासाठी काहीतरी निस्वार्थपणे करायचं असतं, स्वत च्या सुखापेक्षा इतरांना सुखवायचे असतं
आयुष्य असचं जगायचं असतं
दु ख आणि अश्रुंना मनात कोडुन ठेवायचं असतं, हसता नाही आलं तरी हसवायचं असतं,
आयुष्य असचं जगायचं असतं
पंखामध्ये बळ आल्यावर घरटं सोडायचं असतं, आकाशात झेपावुनही धरतीला विसरायचं नसतं,
आयुष्य असचं जगायचं असतं
मरणानं समोर येउन जीव जरी मागितला तरी मागुन मागुन काय मागितलसं असचं म्हणायचं असतं,
आयुष्य असचं जगायचं असतं
इच्छा असो वा नसो जन्मभर वाकायचं असतं, पणं जग सोडताना मात्र समाधानानं जायचं असतं,
आयुष्य असचं जगायचं असतं
आयुष्य असचं जगायचं असतं............
Life is like that??????????
UPSC Civil Services Preliminary Exam - 2009 General Studies Question Paper
UPSC Civil Services Preliminary Exam - 2009 General Studies Question Paper.
Get previous year UPSC Civil Services Preliminary Examination question paper here.
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Get previous year UPSC Civil Services Preliminary Examination question paper here.
Download UPSC question papers
Download 2009 General Studies Question Paper Here Download question papers.Subscribe us via email for more news about UPSC
Tuesday, March 23, 2010
GPAT Question Paper | GATE 2005 Pharmacy Question Paper
GPAT Question Paper is same as previous GATE examination for Pharmacy Graduates
Q.1 to 30 Carry One Mark Each.
1. If the Carr‘s index of a power is 10% then the type of powder flow is
(A) poor (B) excellent (C) very poor (D) good
2. Mixing of semisolids is carried out using
(A) double cone mixer (B) rotating cube mixer
(C) planetary mixer (D) fluidized bed mixer
3. In the preparation of small pox vaccine, the drying process used is
(A) spray drying (B) Vacuum drying
(C) drum drying (D) freeze drying
4. In cosmetic preparations, an antioxidant used in an aqueous system, is
(A) Sodium formaldehyde sulphoxylate (B) a – Tocopherol
(C) Methyl paraben (D) Phenol
5. In the tablet coating process, inadequate spreading of the coating solution before drying causes
(A) Orange peel effect (B) Sticking effect
(C) Blistering effect (D) Picking effect
6. Presence of one of the following characteristics show that the Rauwolfia
serpentine is adulterated with other species of Rauwolfia.
(A) Compound starch grains
(B) Cluster crystals of calcium oxalate
(C) Lignified sclereids (D) Unlignified pericyclic fibres
7. Chinese rhapontic rhubarb can be distinguished from Indian rhubarb by
fluorescence developed in UV light which is:
(A) Deep yellow (B) Deep violet (C) Green (D) Blue
8. Citrus flavonoids are rich in
(A) Aesculetin (B) Fraxin (C) Hesperidin (D) Scopoletin
9. The quantitative values determined for the identification of leaf drugs remain constant throughout the age of the plant EXCEPT
(A) Stomatal number (B) Veinlet termination number
(C) Veinislet number (D) Stomatal index
10. The alkaloid which inhibits the cholinesterase undergoes hydrolysis in solution to give methyl carbamic acid and eseroline is:
(A) Scopolamine (B) Pyridostigmine
(C) Neostigmine (D) Physostigmine
11. Luminescence is the term applied to
(A) absorbed radiation
(B) re-emission of previously absorbed radiation
(C) excited radiation
(D) transmitted radiation
12. Polarogram of a solution containing an electro-reducible substance is obtained by plotting
(A) Current Vs Volume (B) Current Vs Potential
(C) Resistance Vs Time (D) Potential Vs Volume
13. Silica gel used in most of the adsorbent columns contains œ OH groups. So it is
(A) Basic (B) Neutral (C) Acidic
(D) Both acidic and basic
14. The electronic transition possible in Br is:
s s s s s (A) – (B) – - and n * * *
s p p p p s p (C) – - and (D) n – - and * * * *
15. Ferrous ion is very weakly coloured for calorimetric analysis. It can be converted into a highly coloured complex using
(A) H SO (B) PDAB
(C) Thymol blue (D) 1:10 – Phenanthroline
16. Prazepam, Oxazepam, Clonazepam are structurally similar and have the system
(A) 5H-Dibenz(b,f)azepine (B) 1,2,4 – Benzothiadiazine
(C) Benzodiazepine (D) Phenothiazine
17. 11 ß , 21-Dihydroxypregn-4 ene-3,18,20-trione is
(A) Aldosterone (B) Progesterone (C) Cholesterol (D) Cortisone
18. 4, 7 Dichloroquinoline on treatment with 4-amino phenol gives
(A) 7-chloro-2-(2-hydroxy phenyl amino) quinoline
(B) 7-chloro-4-(4-amino phenyl amino) quinoline
(C) 7-chloro-4-(4-hydroxy phenyl amino) quinoline
(D) 4-chloro-7-(4-hydroxy phenyl amino) quinoline
19. Eegonine, a hydrolytic product of cocaine on treatment with chromium trioxide gives a keto acid, which on thermal decarboxylation results in
(A) Atropic acid (B) Tropic acid (C) Pseudo cocaine (D) Tropinone
20. A natural product derivative developed as an antimalarial is
(A) Artemether (B) Paludrine (C) Pyrimethamine (D) Haloffantrine
21. ”Ternary complex‘ refers to the state when
(A) an enzyme forms a covalent complex with its substrate
(B) an enzyme forms a non-covalent complex with either a substrate or a
product
(C) an enzyme that catalyses a reaction with two or more substrates, is
concurrently complexed with both substrates.
(D) an enzyme complexed to a product, just after catalysis
22. The most important clue that helped in the determination of the double helical structure of DNA came from
(A) Chargaffs rules
(B) Hershey-Chase experiment
(C) A very MacLeod œ McCarty experiment
(D) Nirenberg and Khorana‘s codon assignments.
23. Diversity in antibody molecules is brought about by
(A) Post-translational modifications (B) Gene rearrangements
(C) Usage of special genetic codes
(D) Multiple mutations in the polypeptide
24. The etiological agent of infectious mononucleosis, also associated with a form of Burkitt‘s lymphoma is:
(A) Varicella Zoster Virus (B) Epstein Barr Virus
(C) Picorna Virus (D) Papovavirus
25. Tissue plasminogen activator that disperses blood clots, is beneficial if it is given within
(A) 3 days (B) 9 hours (C) 3 hours (D) 24 hours
26. An anticholinesterase which is useful in Alzheimer‘s disease is
(A) Arecolin (B) Donepezil (C) Isoproterenol (D) Clioquinol
27. A drug used as an ophthalmic solution in Herpes keratitis is
(A) Zalcitabine (B) Trifluridine (C) Ritonavir (D) Stavudine
28. A macrolide antibiotic used as a powerful immunosuppressive agent is:
(A) Erythromycin (B) Azithromycin
(C) Tacrolimus (D) Clarithromycin
29. Cytosine arabinoside acts on this phase of the cell cycle
(A) G (B) G (C) M (D) S
30. The Chairman of the Drugs Technical Advisory Board is
(A) The Drugs Controller of India
(B) The Director, Central Drugs Laboratory, Kolkata
(C) The President, Pharmacy Council of India
(D) The Director General of Health Services
Q.31 œ 80 Carry Two Marks Each.
31. Predict the product obtained by treating 6-chloro-3, 5-diamino pyrazin-2-methyl
carboxylate with Guanidine
(A) Amiloride (B) Hydrochlorothiazide
(C) Triamterene (D) Furosemide
32. 2-hydroxy-5, 9-dimethyl-6, 7- benzomorphane derivative is
(A) Pentazocine (B) Hydrocodone
(C) Codeine (D) Buprenorphine
33. The raw materials used for the synthesis of Sulfalen are
(A) 4-acetamido benzene sulfonyl chloride and 2-amino-4-methyl pyrimidine
(B) 4-acetamido benzene sulfonyl chloride and 5-amino-2-ethyl-1,3,4 thiadiazole
(C) 4-acetamido benzene sulfonyl chloride and 5-amino-3,4-dimethyl isoxazole
(D) 4-acetamido benzene sulfonyl chloride and 3-amino-2-methoxy pyrazine
34. Phenoxybenzamine can be prepared from
(A) Phenol and Propylene oxide (B) 3-phenyl propanol
(C) Phthalic anhydride (D) ß -phenyl succinic acid
35. Glycyrrhizin, a sweet principle of liquorice is
(A) K and Mg salts of glycyrrhizinic acid
(B) Na and Mg salts of glycyrrhetinic acid
(C) K and Ca salts of glycyrrhizinic acid
(D) Na and Ca salts of glycyrrhetinic acid
36. Alloploids are polyploids derived from
(A) a single parental species genome
(B) more than one parental species genomes
(C) a plant with haploid number of chromosomes
(D) a plant with diploic number of chromosomes
37. The most effective method of producting virus-free plants is:
(A) Root culture (B) Meristem culture
(C) Somatic embryogenesis (D) Floriculture
38. A person taking orgainic nitrate has to avoid one of the following drugs as it can cause severe hypotension
(A) Aspirin (B) Cholestyramine (C) Warfarin (D) Sildenafil
39. To avoid lithium toxicity, a patient using lithium carbonate for mood disorders should not be prescribed
(A) Acetazolamide (B) Hydrochlorthiazide
(C) Mannitol (D) Porpranolol
40. A selective serotonin reuptake inhibitor used as an antidepressant is
(A) Venlafaxine (B) Selegiline (C) Phenelzine (D) Amoxapine
41. A patient receiving Digoxin for CCF is found to have elevated serum cholesterol.
Which hypolipidemic agent should not be prescribed?
(A) Clofibrate (B) Cholestyramine (C) Lovastatin (D) Niacin
42. In the study of enzyme kinetics, V is said to be attained when
max
(A) there is an excess of free enzyme as compared to the substrate
(B) virtually all of the enzyme is present as the enzyme-substrate complex and concentration of the free enzyme is vanishingly small
(C) the maximum velocity of the reaction in the presence of low substrate
concentration
(D) when the concentration of free enzyme equals that of the enzyme-substrate complex
43. Serum sample of a patient shows elevated levels of – glutamyl transferase. The patient could be suffering from
(A) Kidney disorder (B) Liver disease
(C) Parkinson‘s disease (D) Myocardial infraction
44. Acidfast organisms are seen in the sputum of a 48-year old alcoholic man. A test to confirm whether he needs long term multi-drug treatment for tuberculosis is:
(A) Chest X-ray
(B) Ziehel-Neelsen stain of the sputum
(C) Sputum cytology
(D) Mycobacterial cultures of the sputum
45. The distinguishing features in IR spectra between propionaldehyde and acetone is
(A) Weak-CH stretching and out of plane bending in propionaldehyde
(B) Keto group in acetone
(C) Two methyl groups in acetone
(D) – CH group in pionaldehyde
46. Nephelometric measurements are most sensitive for
(A) Clear solution (B) Concentrated solution
(C) Thick suspensions (D) Very dilute suspensions
47. The number of peaks shown by diethyl ether in an NMR spectrum are
(A) Four (B) Two (C) One (D) Five
48. The half-life for a zero order reaction is calculated using
t k = 0.693 / (B) t k = 2.303 / (C) t ak = 1 / (D) t a k = /2 (A)
49. The biological half-life of procaine in a patient was 35 minutes and its volume of distribution was estimated to be 60 L. The total clearance rate of Procaine is
(A) 1.188L/min (B) 0.115L/min (C) 11.5L/min (D) 5.75L/min
50. The ratio of the void volume to the bulk volume of the packing of the powder is called as
(A) Porosity (B) True density
(C) Granular density (D) Bulk density
51. A co-solvent used in the preparation of parenteral products is:
(A) Benzyl alcohol (B) Methyl alcohol
(C) Dimethyl acetamide (D) Phenol
Q.52-58 are m ultiple selection items. P, Q, R, S are the options. Two of these
options are correct. Choose the correct com bination am ong A, B, C and D.
52. In mass spectroscopy, positively charged ions can be produced by
(P) Heating of the sample
(Q) Bombarding the sample with high energy electrons
(R) Bombarding the sample with high energy protons
(S) Chemical ionization
(A) Q, S (B) Q, R (C) P, R (D) P, S
53. A plastisizer and a high boiling point solvent used in the preparation of nial lacquers are
(P) Butyl stearate (Q) Ethyl lactate (R) Ethyl alcohol (S) Acetone
(A) P, Q (B) Q, S (C) R, S (D) Q, R
54. Two of the following attributes are true for describing the mechanism of action of Thiabendazole.
(P) Neuromuscular blocking causing spastic paralysis
(Q) Blocks the response of the Ascaris muscle to ACH, causins flaccid paralysis in the worms
(R) Inhibits the Helminth specific enzyme fumarate reductase
(S) Arrest nematode cell divisions in metaphase by interfering with microtubule assembly
(A) P, Q (B) R, S (C) Q, S (D) Q, R
55. The colour and flavour of Saffron are due to –
(P) Crocin (Q) Crocetin (R) Safranal
(S) Crepenyic acid
(A) R, S (B) P, R (C) Q, S (D) Q, P
56. Predict the two impurities which are likely to be present in Glipizide
(P) 5-methyl-N-[2-(4-sulphamoyl phenyl) enthyl] pyrazine-2-carboxamide.
(Q) 5-methyl-N-[2-(2-sulphamoyl phenyl) enthyl] pyrazine-2-carboxamide.
(R) Cyclohexanamine
(S) Cyclohexane
(A) P, R (B) P, Q (C) R, Q (D) R, S
57. Calcipotriene, a synthetic Vitamin D analogue has the following attributes
(P) Pronounced antirachitic activity
(Q) Inhibits epidermal cell proliferation and enhances cell differentiation
(R) Used as a topical application in the treatment of moderate plaque psoriasis
(S) Effect on calcium metabolism is 200 times more than Ergocalciferol
(A) Q, R (B) P, Q (C) R, S (D) Q, S
58. Insulin when released from the pancreatic ß cells
(P) Can sequester blood glucose by forming a complex with it.
(Q) gets fully conjugated with glucuronic acid immediately, to be released upon suitable stimuli in normal health.
(R) Acts on the transporter molecules to facilitate glucose movement across the cell membranes.
(S) Increases storage of glucose to glycogen in the liver.
(A) P, R (B) R, S (C) P, S (D) Q, S
Q.59-65 ARE —MATCHING“ exercises. Match Group I with Group II. Choose the correct combination among the alternatives A, B, C and D.
59.
Group I Drugs Group II Titrants used in IP assays
(P) Ascorbic acid (1) TBAH
(Q) Pyridoxine HCI (2) Iodine
(R) Dapsone (3) HClO
(S) Fluorouracil (4) Sodium nitrite
(A) P – 1 Q – 4 R – 3 S – 2 (B) P – 2 Q – 3 R – 4 S – 1
(C) P – 4 Q – 2 R – 1 S – 3 (D) P – 3 Q – 2 R – 4 S – 1
60.
Group I Umbelliferous fruit Group II Diagnostic character
(P) Fenel (1) Wavy sclerenchyma
(Q) Indian Dill (2) Branched and unbranched vittae
(R) Coriander (3) Reticulaterly lignified parenchyma
(S) Anise (4) Lateral ridges with vascular bundles
(A) P – 1 Q – 2 R – 3 S – 4 (B) P – 3 Q – 4 R – 1 S – 2
(C) P – 2 Q – 3 R – 4 S – 1 (D) P – 4 Q – 1 R – 2 S – 3
61.
Group I Enzyme systems responsible for phase 2 Group II Types
conjugation pathways
(P) UDP œ glucuronosyl transferase (1) N-methylation
(Q) ATP-sulfurylase & APS-phosphokinase (2) Sulphate
conjugation
(R) Acly synthatase & transacetylase (3) Glucuronidation
(S) ATP-methionine adenosine transferase (4) Amino acid
conjugation
(A) P – 1 Q – 4 R – 3 S – 2 (B) P – 2 Q – 3 R – 1 S – 4
(C) P – 3 Q – 2 R – 4 S – 1 (D) P – 4 Q – 1 R – 2 S – 3
62.
Group I Drugs Group II Titrants used in IP assays
(P) Ascorbic acid (1) TBAH
(Q) Pyridoxine HCI (2) Iodine
(R) Dapsone (3) HClO
(S) Fluorouracil (4) Sodium nitrite
(A) P – 1 Q – 4 R – 3 S – 2 (B) P – 2 Q – 3 R – 4 S – 1
(C) P – 4 Q – 2 R – 1 S – 3 (D) P – 3 Q – 2 R – 4 S – 1
63.
Group I Group II Explanation
Terms
(P) Saturated (1) Pounds of water vapour carried by one pound of dry air
air under any given set of conditions
(Q) Dew (2) The water vapour is in equilibrium with liquid water at
point the given conditions of temperature and pressure
(R) Humid (3) The volume in cubic feet occupied by one pound dry of
volume air and its accompanying water vapour
(S) Humidity (4) Temperature to which a mixture of air and water
vapour must be cooled in order to become saturated.
(A) P – 1 Q – 4 R – 2 S – 3 (B) P – 4 Q – 3 R – 1 S – 2
(C) P – 3 Q – 1 R – 4 S – 2 (D) P – 2 Q – 4 R – 3 S – 1
64.
Group I Antibiotic Group II Test organism for microbiological assay IP
(P) Bleomycin (1) Pseudomonas aeruginosa
(Q) Nystatin (2) Mycobacterium smegmatis
(R) Carbenicillin (3) Bacillus subtilis
(S) Streptomycin (4) Saccharomyces cerevisiae
(A) P – 2 Q – 4 R – 1 S – 3 (B) P – 4 Q – 1 R – 3 S – 2
(C) P – 3 Q – 2 R – 4 S – 1 (D) P – 3 Q – 1 R – 2 S – 4
65.
Group I Pathoimmunological Group II Drug used in the
condition treatment
(P) Urticaria (1) Cyclosporin
(Q) Autoimmune thrombocytopenia (2) Antihistamines
(R) Rheumatoid arthritis (3) Intravenous immunoglobulin
(S) Organ transplant rejection (4) Glucocorticoids
(A) P – 1 Q – 2 R – 4 S – 3 (B) P – 4 Q – 1 R – 3 S – 2
(C) P – 3 Q – 1 R – 2 S – 4 (D) P – 2 Q – 3 R – 4 S – 1
Data for Q.66 œ 80 are based on the statem ent/problem . Choose the correct answer for each question from among the options A, B, C and D.
Com mon data for questions 66 and 67:
A sample of purchased from the market was evaluated for its Cinnamomum zeylanicum authenticity.
66. It shows
(A) presence of cork and cortex (B) absence of cork and cortex
(C) absence of phloem fibres (D) presence of xylem parenchyma
67. Volatile oil should not be less than
(A) 0.05% (B) 0.20% (C) 0.50% (D) 1.00%
Com mon data for questions 68, 69 and 70:
Chloroacetic acid and hydrazine are treated together with X to get semicarbazido acetic acid in which ring closure takes place to 1-amino hydantoin. It is subsequently treated with 2-diacetoxy methyl-5-nitrofuran to get Nitrofurantoin.
68. Reagetn ”X‘ is
(A) Cuprous chlodride (B) Potassium cyanate
(C) Silver nitrate (D) Mercurous chloride
69. Its IUPAC name is
(A) 1-(5-nitrofurfuryl) hydantoin
(B) 1-(5-nitrofurfurylidene hydroxyl)hydantoin
(C) 1-(5-nitrofurfurylidine amino) hydantoin
(D) 1-(5-aminfurfurylidine nitro) dydantoin
70. Its gastrointestinal tolerance can be improved without interfering with oral absorption by preparing a
(A) solid dispersion (B) prodrug
(C) large crystalline form (Macrodantin) (D) suspension
Com mon data for questions 71 and 72:
A compound ”X‘ with molecular formula C H O exhibits a strong absorption band at 1730cm in IR spectrum. On reduction, it is converted into ”Y‘ which shows a strong band at 3640cm .
71. Assign the band in X to
(A) CH (B) C = C (C) C = O (D) CH C =O
72. The strong band in Y is due to
(A) – C – C (B) – C œ O œ C – (C) = CH (D) – OH
Common data for questions 73, 74 and 75:
In the management of asthma, the drugs used are Salmeterol, Zafirlukast, Budesonide, Nedocromil sodium and Bambuterol.
73. Zafirlukast acts as
(A) ß adrenoceptor agonist
2
(B) Cysteinyl-leukotriene receptor antagnoist
(C) uscarinic receptor antagonist
(D) Antihistamine
74. A prodrug of terbutaline is
(A) Zafirlukast (B) Salmeterol
(C) Bambuterol (D) Nedocromil sodium
75. Warfarin interacts with this antiasthmatic drug and increases prothrombin time
(A) Budesonide (B) Zafirlukast (C) Salmeterol (D) Bambuterol
Com mon data for questions 76, 77 and 78:
In a pharmaceutical industry, batch filtration of liquids where the proportion of solids to liquids is high is to be carried out. The complete recovery of solids is required. After filtration, the filtrate, which is corrosive, gives a crystalline product on evaporation. The liquid tends to deposit scales or crystals on the heating surface during evaporation.
76. A suitable filtration equipment is
(A) Plate and frame filter press (B) Leaf filters
(C) Meta filters (D) Membrane filters
77. The filter aid used in the above filtration is
(A) Sand (B) Nylon fibre cloth
(C) Activated carbon (D) Filter paper
78. A suitable evaporator is
(A) falling film evaporator (B) forced circulation evaporator
(C) vertical evaporator (D) horizontal tube evaporator
Common data for questions 79 and 80:
Isoprenoid biosynthesis is involved in the production of many biologically important compounds such as Cholesterol, Steriod Hormones, Vitamin K, Vitamin E and bile acids.
79. HMG-Co A reductase, a key enzyme in the patway, catalyzes
(A) side chain cleavage in the conversion of cholesterol to steroid hormones
(B) the reduction of the thio-ester group to an alcohol in mevalonate biosyntheis.
(C) the reduction of the hydroxyl group of mevalonate to Vitamin D.
(D) steroid condensation reaction in the biosynthesis of bile acids.
80. The inhibition of HMG-CoA teductase is a strategy used in the treatment of
(A) Familia hyperchlesterolemia (B) Vitamin K deficiency
(C) Inflammation in the joints (D) Hepatic parenchymal disease
Linked Answer Questions: Q.81a to Q85b Carry Two Marks Each.
Statem ent for Linked Answer Questions 81a to 81b:
81. The selective COX-2 inhibitor is (A)
(A) Ketorolac (B) Rofecoxib (C) Indomethacin (D) Naproxen
The drug selected is not to be given, if the patient is already taking (B)
(A) Antiallergic drugs (B) Anxiolytic drugs
(C) Antihypertensive drugs (D) Oral antidiabetic agents
Statem ent for Linked Answer Questions 82a to 82b:
A drug solution has an initial potency of 300 mg/10ml. When stored in a refrigerator for 30 days, its potency was found to be 100 mg/10ml.
82. The rate constant, assuming that the drug solution undergoes first order (A) kinetics, is:
(A) 0.0366 day (B) 0.0074 day (C) 0.0174 day (D) 0.0506 day – 1 – 1 – 1 – 1
Half-life of the drug solution, under these conditions is: (B)
(A) 9.4 days (B) 19 days (C) 47 days (D) 4.7 days
Statement for Linked Answer Questions 83a to 83b:
Ginger is a widely used herbal drug, containing many chemical constituents.
83. The pungent principle present in it, is (A)
(A) Zingiberol (B) Zingiberene (C) Gingerol (D) Cineole
It‘s decomposition product, on boiling with 2% KOH is (B)
(A) Zingiberone (B) Shogaol
(C) Gingediol (D) Gingediol acetate
Statem ent for Linked Answer Questions 84a to 84b:
2, 6-dimethyl phenol and chloroacetone on reaction gives ”X‘, which on treatment with hydroxylamine and hydrochloric acid gives an intermediate product. This on further treatment with Raney nickel in acid, gives the final product.
84. The product ”X‘ is: (A)
(A) 1-(2, 6-Dimethyl phenoxy)-2-propanone
(B) 1-(2, 6-Dimethyl phenoxy)-2-butanone
(C) 1-(2, 6-Dimethyl phenoxy)-2-isopropanone
(D) 1-(2, 6-Dimethyl phenoxy)-2-pentanone
The final product is (B)
(A) 1-methyl-2-(2, 6-xylyloxy)isopropylamine
(B) 1-methyl-2-(2, 6-xylyloxy)ethylamine
(C) 1-methyl-2-(2, 6-xylyloxy)butylamien
(D) 1-methyl-2-(2, 6-xylyloxy)pentylamine
Statem ent for Linked Answer Questions 85a to 85b:
An organic compound ”X‘ has an absorption maxima at 217 nm. Its e is 16,000. the absorbance is 0.64 when the cell length is 1 cm.
85. The molar concentration of ”X‘ is (A)
(A) 5 10 × (B) 4 10 × (C) 4 10 × (D) 5 10 ×
- 5 – 5 – 4 – 2
If the molecular weight is 56.06, its concentration in gms/ml is: (B)
(A) 2.5 10 × (B) 0.25 10 × (C) 5 10 × (D) 2.24 10 ×
GPAT Question Paper
GATE 2005 Pharmacy Question Paper
Q.1 to 30 Carry One Mark Each.
1. If the Carr‘s index of a power is 10% then the type of powder flow is
(A) poor (B) excellent (C) very poor (D) good
2. Mixing of semisolids is carried out using
(A) double cone mixer (B) rotating cube mixer
(C) planetary mixer (D) fluidized bed mixer
3. In the preparation of small pox vaccine, the drying process used is
(A) spray drying (B) Vacuum drying
(C) drum drying (D) freeze drying
4. In cosmetic preparations, an antioxidant used in an aqueous system, is
(A) Sodium formaldehyde sulphoxylate (B) a – Tocopherol
(C) Methyl paraben (D) Phenol
5. In the tablet coating process, inadequate spreading of the coating solution before drying causes
(A) Orange peel effect (B) Sticking effect
(C) Blistering effect (D) Picking effect
6. Presence of one of the following characteristics show that the Rauwolfia
serpentine is adulterated with other species of Rauwolfia.
(A) Compound starch grains
(B) Cluster crystals of calcium oxalate
(C) Lignified sclereids (D) Unlignified pericyclic fibres
7. Chinese rhapontic rhubarb can be distinguished from Indian rhubarb by
fluorescence developed in UV light which is:
(A) Deep yellow (B) Deep violet (C) Green (D) Blue
8. Citrus flavonoids are rich in
(A) Aesculetin (B) Fraxin (C) Hesperidin (D) Scopoletin
9. The quantitative values determined for the identification of leaf drugs remain constant throughout the age of the plant EXCEPT
(A) Stomatal number (B) Veinlet termination number
(C) Veinislet number (D) Stomatal index
10. The alkaloid which inhibits the cholinesterase undergoes hydrolysis in solution to give methyl carbamic acid and eseroline is:
(A) Scopolamine (B) Pyridostigmine
(C) Neostigmine (D) Physostigmine
11. Luminescence is the term applied to
(A) absorbed radiation
(B) re-emission of previously absorbed radiation
(C) excited radiation
(D) transmitted radiation
12. Polarogram of a solution containing an electro-reducible substance is obtained by plotting
(A) Current Vs Volume (B) Current Vs Potential
(C) Resistance Vs Time (D) Potential Vs Volume
13. Silica gel used in most of the adsorbent columns contains œ OH groups. So it is
(A) Basic (B) Neutral (C) Acidic
(D) Both acidic and basic
14. The electronic transition possible in Br is:
s s s s s (A) – (B) – - and n * * *
s p p p p s p (C) – - and (D) n – - and * * * *
15. Ferrous ion is very weakly coloured for calorimetric analysis. It can be converted into a highly coloured complex using
(A) H SO (B) PDAB
(C) Thymol blue (D) 1:10 – Phenanthroline
16. Prazepam, Oxazepam, Clonazepam are structurally similar and have the system
(A) 5H-Dibenz(b,f)azepine (B) 1,2,4 – Benzothiadiazine
(C) Benzodiazepine (D) Phenothiazine
17. 11 ß , 21-Dihydroxypregn-4 ene-3,18,20-trione is
(A) Aldosterone (B) Progesterone (C) Cholesterol (D) Cortisone
18. 4, 7 Dichloroquinoline on treatment with 4-amino phenol gives
(A) 7-chloro-2-(2-hydroxy phenyl amino) quinoline
(B) 7-chloro-4-(4-amino phenyl amino) quinoline
(C) 7-chloro-4-(4-hydroxy phenyl amino) quinoline
(D) 4-chloro-7-(4-hydroxy phenyl amino) quinoline
19. Eegonine, a hydrolytic product of cocaine on treatment with chromium trioxide gives a keto acid, which on thermal decarboxylation results in
(A) Atropic acid (B) Tropic acid (C) Pseudo cocaine (D) Tropinone
20. A natural product derivative developed as an antimalarial is
(A) Artemether (B) Paludrine (C) Pyrimethamine (D) Haloffantrine
21. ”Ternary complex‘ refers to the state when
(A) an enzyme forms a covalent complex with its substrate
(B) an enzyme forms a non-covalent complex with either a substrate or a
product
(C) an enzyme that catalyses a reaction with two or more substrates, is
concurrently complexed with both substrates.
(D) an enzyme complexed to a product, just after catalysis
22. The most important clue that helped in the determination of the double helical structure of DNA came from
(A) Chargaffs rules
(B) Hershey-Chase experiment
(C) A very MacLeod œ McCarty experiment
(D) Nirenberg and Khorana‘s codon assignments.
23. Diversity in antibody molecules is brought about by
(A) Post-translational modifications (B) Gene rearrangements
(C) Usage of special genetic codes
(D) Multiple mutations in the polypeptide
24. The etiological agent of infectious mononucleosis, also associated with a form of Burkitt‘s lymphoma is:
(A) Varicella Zoster Virus (B) Epstein Barr Virus
(C) Picorna Virus (D) Papovavirus
25. Tissue plasminogen activator that disperses blood clots, is beneficial if it is given within
(A) 3 days (B) 9 hours (C) 3 hours (D) 24 hours
26. An anticholinesterase which is useful in Alzheimer‘s disease is
(A) Arecolin (B) Donepezil (C) Isoproterenol (D) Clioquinol
27. A drug used as an ophthalmic solution in Herpes keratitis is
(A) Zalcitabine (B) Trifluridine (C) Ritonavir (D) Stavudine
28. A macrolide antibiotic used as a powerful immunosuppressive agent is:
(A) Erythromycin (B) Azithromycin
(C) Tacrolimus (D) Clarithromycin
29. Cytosine arabinoside acts on this phase of the cell cycle
(A) G (B) G (C) M (D) S
30. The Chairman of the Drugs Technical Advisory Board is
(A) The Drugs Controller of India
(B) The Director, Central Drugs Laboratory, Kolkata
(C) The President, Pharmacy Council of India
(D) The Director General of Health Services
Q.31 œ 80 Carry Two Marks Each.
31. Predict the product obtained by treating 6-chloro-3, 5-diamino pyrazin-2-methyl
carboxylate with Guanidine
(A) Amiloride (B) Hydrochlorothiazide
(C) Triamterene (D) Furosemide
32. 2-hydroxy-5, 9-dimethyl-6, 7- benzomorphane derivative is
(A) Pentazocine (B) Hydrocodone
(C) Codeine (D) Buprenorphine
33. The raw materials used for the synthesis of Sulfalen are
(A) 4-acetamido benzene sulfonyl chloride and 2-amino-4-methyl pyrimidine
(B) 4-acetamido benzene sulfonyl chloride and 5-amino-2-ethyl-1,3,4 thiadiazole
(C) 4-acetamido benzene sulfonyl chloride and 5-amino-3,4-dimethyl isoxazole
(D) 4-acetamido benzene sulfonyl chloride and 3-amino-2-methoxy pyrazine
34. Phenoxybenzamine can be prepared from
(A) Phenol and Propylene oxide (B) 3-phenyl propanol
(C) Phthalic anhydride (D) ß -phenyl succinic acid
35. Glycyrrhizin, a sweet principle of liquorice is
(A) K and Mg salts of glycyrrhizinic acid
(B) Na and Mg salts of glycyrrhetinic acid
(C) K and Ca salts of glycyrrhizinic acid
(D) Na and Ca salts of glycyrrhetinic acid
36. Alloploids are polyploids derived from
(A) a single parental species genome
(B) more than one parental species genomes
(C) a plant with haploid number of chromosomes
(D) a plant with diploic number of chromosomes
37. The most effective method of producting virus-free plants is:
(A) Root culture (B) Meristem culture
(C) Somatic embryogenesis (D) Floriculture
38. A person taking orgainic nitrate has to avoid one of the following drugs as it can cause severe hypotension
(A) Aspirin (B) Cholestyramine (C) Warfarin (D) Sildenafil
39. To avoid lithium toxicity, a patient using lithium carbonate for mood disorders should not be prescribed
(A) Acetazolamide (B) Hydrochlorthiazide
(C) Mannitol (D) Porpranolol
40. A selective serotonin reuptake inhibitor used as an antidepressant is
(A) Venlafaxine (B) Selegiline (C) Phenelzine (D) Amoxapine
41. A patient receiving Digoxin for CCF is found to have elevated serum cholesterol.
Which hypolipidemic agent should not be prescribed?
(A) Clofibrate (B) Cholestyramine (C) Lovastatin (D) Niacin
42. In the study of enzyme kinetics, V is said to be attained when
max
(A) there is an excess of free enzyme as compared to the substrate
(B) virtually all of the enzyme is present as the enzyme-substrate complex and concentration of the free enzyme is vanishingly small
(C) the maximum velocity of the reaction in the presence of low substrate
concentration
(D) when the concentration of free enzyme equals that of the enzyme-substrate complex
43. Serum sample of a patient shows elevated levels of – glutamyl transferase. The patient could be suffering from
(A) Kidney disorder (B) Liver disease
(C) Parkinson‘s disease (D) Myocardial infraction
44. Acidfast organisms are seen in the sputum of a 48-year old alcoholic man. A test to confirm whether he needs long term multi-drug treatment for tuberculosis is:
(A) Chest X-ray
(B) Ziehel-Neelsen stain of the sputum
(C) Sputum cytology
(D) Mycobacterial cultures of the sputum
45. The distinguishing features in IR spectra between propionaldehyde and acetone is
(A) Weak-CH stretching and out of plane bending in propionaldehyde
(B) Keto group in acetone
(C) Two methyl groups in acetone
(D) – CH group in pionaldehyde
46. Nephelometric measurements are most sensitive for
(A) Clear solution (B) Concentrated solution
(C) Thick suspensions (D) Very dilute suspensions
47. The number of peaks shown by diethyl ether in an NMR spectrum are
(A) Four (B) Two (C) One (D) Five
48. The half-life for a zero order reaction is calculated using
t k = 0.693 / (B) t k = 2.303 / (C) t ak = 1 / (D) t a k = /2 (A)
49. The biological half-life of procaine in a patient was 35 minutes and its volume of distribution was estimated to be 60 L. The total clearance rate of Procaine is
(A) 1.188L/min (B) 0.115L/min (C) 11.5L/min (D) 5.75L/min
50. The ratio of the void volume to the bulk volume of the packing of the powder is called as
(A) Porosity (B) True density
(C) Granular density (D) Bulk density
51. A co-solvent used in the preparation of parenteral products is:
(A) Benzyl alcohol (B) Methyl alcohol
(C) Dimethyl acetamide (D) Phenol
Q.52-58 are m ultiple selection items. P, Q, R, S are the options. Two of these
options are correct. Choose the correct com bination am ong A, B, C and D.
52. In mass spectroscopy, positively charged ions can be produced by
(P) Heating of the sample
(Q) Bombarding the sample with high energy electrons
(R) Bombarding the sample with high energy protons
(S) Chemical ionization
(A) Q, S (B) Q, R (C) P, R (D) P, S
53. A plastisizer and a high boiling point solvent used in the preparation of nial lacquers are
(P) Butyl stearate (Q) Ethyl lactate (R) Ethyl alcohol (S) Acetone
(A) P, Q (B) Q, S (C) R, S (D) Q, R
54. Two of the following attributes are true for describing the mechanism of action of Thiabendazole.
(P) Neuromuscular blocking causing spastic paralysis
(Q) Blocks the response of the Ascaris muscle to ACH, causins flaccid paralysis in the worms
(R) Inhibits the Helminth specific enzyme fumarate reductase
(S) Arrest nematode cell divisions in metaphase by interfering with microtubule assembly
(A) P, Q (B) R, S (C) Q, S (D) Q, R
55. The colour and flavour of Saffron are due to –
(P) Crocin (Q) Crocetin (R) Safranal
(S) Crepenyic acid
(A) R, S (B) P, R (C) Q, S (D) Q, P
56. Predict the two impurities which are likely to be present in Glipizide
(P) 5-methyl-N-[2-(4-sulphamoyl phenyl) enthyl] pyrazine-2-carboxamide.
(Q) 5-methyl-N-[2-(2-sulphamoyl phenyl) enthyl] pyrazine-2-carboxamide.
(R) Cyclohexanamine
(S) Cyclohexane
(A) P, R (B) P, Q (C) R, Q (D) R, S
57. Calcipotriene, a synthetic Vitamin D analogue has the following attributes
(P) Pronounced antirachitic activity
(Q) Inhibits epidermal cell proliferation and enhances cell differentiation
(R) Used as a topical application in the treatment of moderate plaque psoriasis
(S) Effect on calcium metabolism is 200 times more than Ergocalciferol
(A) Q, R (B) P, Q (C) R, S (D) Q, S
58. Insulin when released from the pancreatic ß cells
(P) Can sequester blood glucose by forming a complex with it.
(Q) gets fully conjugated with glucuronic acid immediately, to be released upon suitable stimuli in normal health.
(R) Acts on the transporter molecules to facilitate glucose movement across the cell membranes.
(S) Increases storage of glucose to glycogen in the liver.
(A) P, R (B) R, S (C) P, S (D) Q, S
Q.59-65 ARE —MATCHING“ exercises. Match Group I with Group II. Choose the correct combination among the alternatives A, B, C and D.
59.
Group I Drugs Group II Titrants used in IP assays
(P) Ascorbic acid (1) TBAH
(Q) Pyridoxine HCI (2) Iodine
(R) Dapsone (3) HClO
(S) Fluorouracil (4) Sodium nitrite
(A) P – 1 Q – 4 R – 3 S – 2 (B) P – 2 Q – 3 R – 4 S – 1
(C) P – 4 Q – 2 R – 1 S – 3 (D) P – 3 Q – 2 R – 4 S – 1
60.
Group I Umbelliferous fruit Group II Diagnostic character
(P) Fenel (1) Wavy sclerenchyma
(Q) Indian Dill (2) Branched and unbranched vittae
(R) Coriander (3) Reticulaterly lignified parenchyma
(S) Anise (4) Lateral ridges with vascular bundles
(A) P – 1 Q – 2 R – 3 S – 4 (B) P – 3 Q – 4 R – 1 S – 2
(C) P – 2 Q – 3 R – 4 S – 1 (D) P – 4 Q – 1 R – 2 S – 3
61.
Group I Enzyme systems responsible for phase 2 Group II Types
conjugation pathways
(P) UDP œ glucuronosyl transferase (1) N-methylation
(Q) ATP-sulfurylase & APS-phosphokinase (2) Sulphate
conjugation
(R) Acly synthatase & transacetylase (3) Glucuronidation
(S) ATP-methionine adenosine transferase (4) Amino acid
conjugation
(A) P – 1 Q – 4 R – 3 S – 2 (B) P – 2 Q – 3 R – 1 S – 4
(C) P – 3 Q – 2 R – 4 S – 1 (D) P – 4 Q – 1 R – 2 S – 3
62.
Group I Drugs Group II Titrants used in IP assays
(P) Ascorbic acid (1) TBAH
(Q) Pyridoxine HCI (2) Iodine
(R) Dapsone (3) HClO
(S) Fluorouracil (4) Sodium nitrite
(A) P – 1 Q – 4 R – 3 S – 2 (B) P – 2 Q – 3 R – 4 S – 1
(C) P – 4 Q – 2 R – 1 S – 3 (D) P – 3 Q – 2 R – 4 S – 1
63.
Group I Group II Explanation
Terms
(P) Saturated (1) Pounds of water vapour carried by one pound of dry air
air under any given set of conditions
(Q) Dew (2) The water vapour is in equilibrium with liquid water at
point the given conditions of temperature and pressure
(R) Humid (3) The volume in cubic feet occupied by one pound dry of
volume air and its accompanying water vapour
(S) Humidity (4) Temperature to which a mixture of air and water
vapour must be cooled in order to become saturated.
(A) P – 1 Q – 4 R – 2 S – 3 (B) P – 4 Q – 3 R – 1 S – 2
(C) P – 3 Q – 1 R – 4 S – 2 (D) P – 2 Q – 4 R – 3 S – 1
64.
Group I Antibiotic Group II Test organism for microbiological assay IP
(P) Bleomycin (1) Pseudomonas aeruginosa
(Q) Nystatin (2) Mycobacterium smegmatis
(R) Carbenicillin (3) Bacillus subtilis
(S) Streptomycin (4) Saccharomyces cerevisiae
(A) P – 2 Q – 4 R – 1 S – 3 (B) P – 4 Q – 1 R – 3 S – 2
(C) P – 3 Q – 2 R – 4 S – 1 (D) P – 3 Q – 1 R – 2 S – 4
65.
Group I Pathoimmunological Group II Drug used in the
condition treatment
(P) Urticaria (1) Cyclosporin
(Q) Autoimmune thrombocytopenia (2) Antihistamines
(R) Rheumatoid arthritis (3) Intravenous immunoglobulin
(S) Organ transplant rejection (4) Glucocorticoids
(A) P – 1 Q – 2 R – 4 S – 3 (B) P – 4 Q – 1 R – 3 S – 2
(C) P – 3 Q – 1 R – 2 S – 4 (D) P – 2 Q – 3 R – 4 S – 1
Data for Q.66 œ 80 are based on the statem ent/problem . Choose the correct answer for each question from among the options A, B, C and D.
Com mon data for questions 66 and 67:
A sample of purchased from the market was evaluated for its Cinnamomum zeylanicum authenticity.
66. It shows
(A) presence of cork and cortex (B) absence of cork and cortex
(C) absence of phloem fibres (D) presence of xylem parenchyma
67. Volatile oil should not be less than
(A) 0.05% (B) 0.20% (C) 0.50% (D) 1.00%
Com mon data for questions 68, 69 and 70:
Chloroacetic acid and hydrazine are treated together with X to get semicarbazido acetic acid in which ring closure takes place to 1-amino hydantoin. It is subsequently treated with 2-diacetoxy methyl-5-nitrofuran to get Nitrofurantoin.
68. Reagetn ”X‘ is
(A) Cuprous chlodride (B) Potassium cyanate
(C) Silver nitrate (D) Mercurous chloride
69. Its IUPAC name is
(A) 1-(5-nitrofurfuryl) hydantoin
(B) 1-(5-nitrofurfurylidene hydroxyl)hydantoin
(C) 1-(5-nitrofurfurylidine amino) hydantoin
(D) 1-(5-aminfurfurylidine nitro) dydantoin
70. Its gastrointestinal tolerance can be improved without interfering with oral absorption by preparing a
(A) solid dispersion (B) prodrug
(C) large crystalline form (Macrodantin) (D) suspension
Com mon data for questions 71 and 72:
A compound ”X‘ with molecular formula C H O exhibits a strong absorption band at 1730cm in IR spectrum. On reduction, it is converted into ”Y‘ which shows a strong band at 3640cm .
71. Assign the band in X to
(A) CH (B) C = C (C) C = O (D) CH C =O
72. The strong band in Y is due to
(A) – C – C (B) – C œ O œ C – (C) = CH (D) – OH
Common data for questions 73, 74 and 75:
In the management of asthma, the drugs used are Salmeterol, Zafirlukast, Budesonide, Nedocromil sodium and Bambuterol.
73. Zafirlukast acts as
(A) ß adrenoceptor agonist
2
(B) Cysteinyl-leukotriene receptor antagnoist
(C) uscarinic receptor antagonist
(D) Antihistamine
74. A prodrug of terbutaline is
(A) Zafirlukast (B) Salmeterol
(C) Bambuterol (D) Nedocromil sodium
75. Warfarin interacts with this antiasthmatic drug and increases prothrombin time
(A) Budesonide (B) Zafirlukast (C) Salmeterol (D) Bambuterol
Com mon data for questions 76, 77 and 78:
In a pharmaceutical industry, batch filtration of liquids where the proportion of solids to liquids is high is to be carried out. The complete recovery of solids is required. After filtration, the filtrate, which is corrosive, gives a crystalline product on evaporation. The liquid tends to deposit scales or crystals on the heating surface during evaporation.
76. A suitable filtration equipment is
(A) Plate and frame filter press (B) Leaf filters
(C) Meta filters (D) Membrane filters
77. The filter aid used in the above filtration is
(A) Sand (B) Nylon fibre cloth
(C) Activated carbon (D) Filter paper
78. A suitable evaporator is
(A) falling film evaporator (B) forced circulation evaporator
(C) vertical evaporator (D) horizontal tube evaporator
Common data for questions 79 and 80:
Isoprenoid biosynthesis is involved in the production of many biologically important compounds such as Cholesterol, Steriod Hormones, Vitamin K, Vitamin E and bile acids.
79. HMG-Co A reductase, a key enzyme in the patway, catalyzes
(A) side chain cleavage in the conversion of cholesterol to steroid hormones
(B) the reduction of the thio-ester group to an alcohol in mevalonate biosyntheis.
(C) the reduction of the hydroxyl group of mevalonate to Vitamin D.
(D) steroid condensation reaction in the biosynthesis of bile acids.
80. The inhibition of HMG-CoA teductase is a strategy used in the treatment of
(A) Familia hyperchlesterolemia (B) Vitamin K deficiency
(C) Inflammation in the joints (D) Hepatic parenchymal disease
Linked Answer Questions: Q.81a to Q85b Carry Two Marks Each.
Statem ent for Linked Answer Questions 81a to 81b:
81. The selective COX-2 inhibitor is (A)
(A) Ketorolac (B) Rofecoxib (C) Indomethacin (D) Naproxen
The drug selected is not to be given, if the patient is already taking (B)
(A) Antiallergic drugs (B) Anxiolytic drugs
(C) Antihypertensive drugs (D) Oral antidiabetic agents
Statem ent for Linked Answer Questions 82a to 82b:
A drug solution has an initial potency of 300 mg/10ml. When stored in a refrigerator for 30 days, its potency was found to be 100 mg/10ml.
82. The rate constant, assuming that the drug solution undergoes first order (A) kinetics, is:
(A) 0.0366 day (B) 0.0074 day (C) 0.0174 day (D) 0.0506 day – 1 – 1 – 1 – 1
Half-life of the drug solution, under these conditions is: (B)
(A) 9.4 days (B) 19 days (C) 47 days (D) 4.7 days
Statement for Linked Answer Questions 83a to 83b:
Ginger is a widely used herbal drug, containing many chemical constituents.
83. The pungent principle present in it, is (A)
(A) Zingiberol (B) Zingiberene (C) Gingerol (D) Cineole
It‘s decomposition product, on boiling with 2% KOH is (B)
(A) Zingiberone (B) Shogaol
(C) Gingediol (D) Gingediol acetate
Statem ent for Linked Answer Questions 84a to 84b:
2, 6-dimethyl phenol and chloroacetone on reaction gives ”X‘, which on treatment with hydroxylamine and hydrochloric acid gives an intermediate product. This on further treatment with Raney nickel in acid, gives the final product.
84. The product ”X‘ is: (A)
(A) 1-(2, 6-Dimethyl phenoxy)-2-propanone
(B) 1-(2, 6-Dimethyl phenoxy)-2-butanone
(C) 1-(2, 6-Dimethyl phenoxy)-2-isopropanone
(D) 1-(2, 6-Dimethyl phenoxy)-2-pentanone
The final product is (B)
(A) 1-methyl-2-(2, 6-xylyloxy)isopropylamine
(B) 1-methyl-2-(2, 6-xylyloxy)ethylamine
(C) 1-methyl-2-(2, 6-xylyloxy)butylamien
(D) 1-methyl-2-(2, 6-xylyloxy)pentylamine
Statem ent for Linked Answer Questions 85a to 85b:
An organic compound ”X‘ has an absorption maxima at 217 nm. Its e is 16,000. the absorbance is 0.64 when the cell length is 1 cm.
85. The molar concentration of ”X‘ is (A)
(A) 5 10 × (B) 4 10 × (C) 4 10 × (D) 5 10 ×
- 5 – 5 – 4 – 2
If the molecular weight is 56.06, its concentration in gms/ml is: (B)
(A) 2.5 10 × (B) 0.25 10 × (C) 5 10 × (D) 2.24 10 ×
Graduate Pharmacy Aptitude Test GPAT
Monday, March 22, 2010
GPAT Pharmacy Question Paper | Gate 2003 Pharmacy question paper
GPAT Pharmacy Question Paper Gate 2003 Pharmacy question paper
try to solve Gpat question paper Here Gate 2003 question paper
try to solve Gpat question paper Here Gate 2003 question paper
IPL Matches Nagpur VCA Jamatha Deccan Chargers Ticket Online
Watch IPL Nagpur Matches in VCA Jamatha Nagpur stadium.
Now Nagpur Host Deccan Chargers 3 IPL matches as home ground.
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Buy your IPL Nagpur Tickets here IPL TICKETS Nagpur
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IPL Matches in Nagpur Tickit avaibility
Welcome you in Nagpur the city of Oranges and also known Orange City.
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Thursday, March 18, 2010
I Want Once Again go back to My School मला पुन्हा एकदा शाळेत जायचे आहे,
I Want Once Again go back to My School,
मला पुन्हा एकदा शाळेत जायचे आहे,
धावत जाउन माज्या रोजच्या बाकावर बसायेचे आहे,
रोज सकाळी रांगेत लागुन जोमाने राष्ट्रगीत म्हणायचे आहे,
नव्या वहिचा वास घेउन पहिल्या पानावर माजे नव लिहायचे आहे,
माला एकदा पुन्हा शाळेत जायचे आहे.
to be continued............
मला पुन्हा एकदा शाळेत जायचे आहे,
धावत जाउन माज्या रोजच्या बाकावर बसायेचे आहे,
रोज सकाळी रांगेत लागुन जोमाने राष्ट्रगीत म्हणायचे आहे,
नव्या वहिचा वास घेउन पहिल्या पानावर माजे नव लिहायचे आहे,
माला एकदा पुन्हा शाळेत जायचे आहे.
to be continued............
Wednesday, March 17, 2010
Vacancy In Central East South Railway Recruitment Board Bilaspur Pharmacist etc
Recruitment In Railway Pharmacist, Staf Nurse, Dental Highgenist, Lab Asst, Physiotherapist Railway Recruitment Board Bilaspur Paramedical Job Openings.
Recruitment Railway Bharti Board Bilaspur
Monday, March 15, 2010
Happy Gudi Padawa & Happy Marathi New year 1932
Dear friends,
Happy Gudi Padawa & Happy Marathi New year 1932.
शके १९३२ मराठी नविन वर्ष स्वागत स्वागत स्वागत १९३२ स्वागत स्वागत १९३२ स्वागत आणि अभिनन्दन.
This new year is very very succesive for you.
God will give you all happy things to you.
Enjoy the new marathi year 1932 and The festival Gudi padawa.
आपण सर्वाना मराठी नविन वर्ष्याच्या हार्दिक शुभकामना आणि गुडी पाडवा च्या शुभेच्या.
Happy Gudi Padawa & Happy Marathi New year 1932.
शके १९३२ मराठी नविन वर्ष स्वागत स्वागत स्वागत १९३२ स्वागत स्वागत १९३२ स्वागत आणि अभिनन्दन.
This new year is very very succesive for you.
God will give you all happy things to you.
Enjoy the new marathi year 1932 and The festival Gudi padawa.
आपण सर्वाना मराठी नविन वर्ष्याच्या हार्दिक शुभकामना आणि गुडी पाडवा च्या शुभेच्या.
Saturday, March 13, 2010
Friday, March 12, 2010
साधं सोपं आयुष्य Marathi Poem
The Bueatiful Marathi Poem about Life,
साधं सोपं आयुष्य
साधं सोपं जगायचं
हसावंसं वाटलं तर हसायचं
रडावंसं वाटलं तर रडायचं
जसं बोलतो तसं नेहमी
वागायला थोडंच हवं
प्रत्येक वागण्याचं कारण
सांगायला थोडंच हवं
ज्यांना सांगायचं त्यांना सांगायचं
ज्यांना टांगायचं त्यांना टांगायचं!
मनात जे जे येतं ते ते
करून बघितलं पाहिजे आपण
जसं जगावं वाटतं तसंच
जगून बघितलं पाहिजे आपण
करावंसं वाटेल ते करायचं
जगावंसं वाटेल तसं जगायचं...
आपला दिवस होतो
जेंव्हा जाग आपल्याला येते
आपली रात्र होते जेंव्हा
झोप आपल्याला येते
झोप आली की झोपायचं
जाग आली की उठायचं!
पिठलं भाकरी मजेत खायची
जशी पक्वान्नं पानात
आपल्या घरात असं वावरायचं
जसा सिंह रानात!
आपल्या जेवणाचं, आपल्या जगण्याचं
आपणच कौतुक करायचं
असेलही चंद्र मोठा
त्याचं कौतुक कशाला एवढं
जगात दुसरं चांदणं नाही
आपल्या हसण्या एवढं!
आपणच आपलं चांदणं बनून
घरभर शिंपत रहायचं
साधं सोपं आयुष्य
साधं सोपं जगायचं
हसावंसं वाटलं तर हसायचं
रडावंसं वाटलं तर रडायचं.........
साधं सोपं आयुष्य
साधं सोपं जगायचं
हसावंसं वाटलं तर हसायचं
रडावंसं वाटलं तर रडायचं
जसं बोलतो तसं नेहमी
वागायला थोडंच हवं
प्रत्येक वागण्याचं कारण
सांगायला थोडंच हवं
ज्यांना सांगायचं त्यांना सांगायचं
ज्यांना टांगायचं त्यांना टांगायचं!
मनात जे जे येतं ते ते
करून बघितलं पाहिजे आपण
जसं जगावं वाटतं तसंच
जगून बघितलं पाहिजे आपण
करावंसं वाटेल ते करायचं
जगावंसं वाटेल तसं जगायचं...
आपला दिवस होतो
जेंव्हा जाग आपल्याला येते
आपली रात्र होते जेंव्हा
झोप आपल्याला येते
झोप आली की झोपायचं
जाग आली की उठायचं!
पिठलं भाकरी मजेत खायची
जशी पक्वान्नं पानात
आपल्या घरात असं वावरायचं
जसा सिंह रानात!
आपल्या जेवणाचं, आपल्या जगण्याचं
आपणच कौतुक करायचं
असेलही चंद्र मोठा
त्याचं कौतुक कशाला एवढं
जगात दुसरं चांदणं नाही
आपल्या हसण्या एवढं!
आपणच आपलं चांदणं बनून
घरभर शिंपत रहायचं
साधं सोपं आयुष्य
साधं सोपं जगायचं
हसावंसं वाटलं तर हसायचं
रडावंसं वाटलं तर रडायचं.........
Monday, March 8, 2010
MAHARASHTRA FOREST SERVICES EXAM - 2008 Interview Shedule Change
MAHARASHTRA PUBLIC SERVICE COMMISSION
MAHARASHTRA FOREST SERVICES EXAM - 2008 Interview Shedule Changed.
MAHARASHTRA FOREST SERVICES EXAM - 2008 Interview start from 17/03/2010 at Morning 08.00 am. To 22/03/2010.
Interview Venue :
Old Government Rest House,
(Circuit House), 29,
Queens Garden,
Pune 411 001
Please conform your Intervie shedule on official website here:
http://mpsc.maharashtra.gov.in/english/dcmNew/news/interviewMainShow.php?newsTyp=deptNews&searchType=dept&language=marathi&deptCode=0105&boardId=57
All the best for all Candidates, Do well.
MAHARASHTRA FOREST SERVICES EXAM - 2008 Interview Shedule Changed.
New Shedule for Pune Centere
as Follow,MAHARASHTRA FOREST SERVICES EXAM - 2008 Interview start from 17/03/2010 at Morning 08.00 am. To 22/03/2010.
Interview Venue :
Old Government Rest House,
(Circuit House), 29,
Queens Garden,
Pune 411 001
Please conform your Intervie shedule on official website here:
http://mpsc.maharashtra.gov.in/english/dcmNew/news/interviewMainShow.php?newsTyp=deptNews&searchType=dept&language=marathi&deptCode=0105&boardId=57
All the best for all Candidates, Do well.
Thursday, March 4, 2010
Life is Very Beautiful आयुष्य खूप सुंदर आहे Marathi poem
Life is Very Beautiful Marathi poem
आयुष्य खूप सुंदर आहे,
सोबत कुणी नसलं तरी,
एकट्यानेच ते फुलवत रहा,
वादळात सगळं वाहून गेल,
म्हणुन रडत बसू नका,
वेगळ अस काही, माझ्यात खास नाही असं म्हणून उदास होऊ नका
मृगाकडे कस्तुरी आहे,
फुलात गंध आहे,
सागराकडे अथांगता आहे,
माझ्याकडे काय आहे, असं म्हणून रडू नका,
अंधाराला जाळणरा एक सूर्य तुमच्यातही लपला आहे.
आव्हाहन करा त्या सूर्याला!!!!! मग उगवेल तो तुमच्या आयुष्यात नवीन क्षितिज घेऊन.
अंधारामय रात्र संपवून सोनेरी किरणांनी सजून
मग रोजच उगवेल एक नवी सकाळ,
उत्साह ध्येयाने भारुन म्हणून म्हणते.........
आयुष्य खूप सुंदर आहे,
सोबत कुणी नसल तरी
एकट्यानेच ते फुलवत रहा......
आयुष्य खूप सुंदर आहे,
सोबत कुणी नसलं तरी,
एकट्यानेच ते फुलवत रहा,
वादळात सगळं वाहून गेल,
म्हणुन रडत बसू नका,
वेगळ अस काही, माझ्यात खास नाही असं म्हणून उदास होऊ नका
मृगाकडे कस्तुरी आहे,
फुलात गंध आहे,
सागराकडे अथांगता आहे,
माझ्याकडे काय आहे, असं म्हणून रडू नका,
अंधाराला जाळणरा एक सूर्य तुमच्यातही लपला आहे.
आव्हाहन करा त्या सूर्याला!!!!! मग उगवेल तो तुमच्या आयुष्यात नवीन क्षितिज घेऊन.
अंधारामय रात्र संपवून सोनेरी किरणांनी सजून
मग रोजच उगवेल एक नवी सकाळ,
उत्साह ध्येयाने भारुन म्हणून म्हणते.........
आयुष्य खूप सुंदर आहे,
सोबत कुणी नसल तरी
एकट्यानेच ते फुलवत रहा......
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